Arch Intern Med roundup: diets, delays and disclosure

Arch intern MedThe journal Archives of Internal Medicine has a several cracking research papers this week.

Low carb dieters are grumpier than those on low fat diets

First up is Brinkworth et al.‘s research on the long-term psychological effects of low carbohydrate diets compared with low fat diets.

In this study, 106 overweight and obese individuals were randomly assigned to receive a low carbohydrate, high fat diet or a high carbohydrate, low fat plan. After one year, those participants on the low carbohydrate diet were more likely to be anxious, depressed, angry or confused than were those on the low fat diet. Both diets had the same number of calories and produced a similar amount of weight loss (13.7kg).

The authors suggest that the social difficulty of adhering to a low carbohydrate plan, which is counter to the typical Western diet full of pasta and bread, may be in part responsible for the mood deterioration in the low carb group. Alternatively, protein and fat intake may differently affect brain levels of serotonin, the so-called “happy hormone” (NB: its a neurotransmitter, not a hormone).

The Daily Telegraph points out that the infamous meat-heavy Atkins diet is essentially a low carb, high fat plan – bad news for all the celebrity fans.  Suddenly the term “hangry” makes more sense…

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Brinkworth GD, Buckley JD, Noakes M, Clifton PM, & Wilson CJ (2009) Long-term Effects of a Very Low-Carbohydrate Diet and a Low-Fat Diet on Mood and Cognitive Function. Arch Intern Med 169 (20): 1873-1880. URL: Here

Fewer than ever emergency department patients are being seen on time

Next is Horwitz and Bradley’s paper on wait times to see a doctor in US emergency departments. The authors assessed more than 150,000 visits and found that only one in four patients were seen within the target triage time in 2006, compared with one in five in 2007.  By 2006, the odds of being seen on time were 30% lower than in 1997.

Interestingly, the proportion of patients seen on time did not differ on the basis of insurance status or race/ethnicity.  As the LA Times put it, “The conventional wisdom that throngs of low-income, uninsured people who use the ER as a substitute for primary care visits are to blame is wrong.”

Instead, the change in wait times was driven by delays in attending to emergency cases, who were 87% less likely to be seen within the target time than nonurgent cases.

As the authors says, “The percentage of patients in the emergency department who are seen by a physician within the time recommended … is at its lowest point in at least 10 years”

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Horwitz LI & Bradley EH (2009) Percentage of US Emergency Department Patients Seen Within the Recommended Triage Time: 1997 to 2006. Arch Intern Med 169 (20): 1857-1865. URL: Here

GP visits are getting longer and better

Timings are also increasing in primary care, but rather than waiting times the time patients spend with their doctor is growing, according to Chen and colleagues.

Visits by adults to primary care physicians in the US between 1997 and 2005 increased by 10%, from 273 million to 338 million annually.  During this period, the mean duration of visit increased from 18.0 minutes to 20.8 minutes. Visit duration increased the most for people with any form of arthritis – by 5.9 minutes.

The increase in time spent with physicians seemed to be down to doctors spending longer counselling their patients. Visits for counselling or screening generally took 2.6-4.2 minutes longer than visits in which patients did not receive these services, whereas there was no change in the duration of visits in which doctors simply provided medication.

“Although it is possible that physicians have become less efficient over time, it is far more likely that visit duration has increased because it takes more resources or time to care for an older and sicker population,” the authors conclude. These findings thus contradict the belief that doctors are shaving time off consultations to meet efficiency goals, says the Wall Street Journal.

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Chen LM, Farwell WR, & Jha AK (2009) Primary Care Visit Duration and Quality: Does Good Care Take Longer? Arch Intern Med 169 (20): 1866-1872. URL: Here

Patients rate care better if doctors disclose mistakes

Finally, López et al. looked at how health professional disclosure of adverse events – an injury caused by some aspect of medical care and not by the underlying medical condition – affects patient perceptions of care.  They found that in patients who experienced an adverse event in hospital, those whose doctor told them about the event were likely to rate their care more highly than patients whose caregivers did not address the problem.

A total of 845 adverse events were reported in this sample of almost 2,600 acute care adult patients, but only 40% of these were disclosed. However, disclosure of preventable and nonpreventable events was associated with high ratings of quality of care. In addition, patients who felt that they were able to protect themselves from adverse events were likely to rate their care favourably.

On the other hand, patients who experienced medical accidents that were preventable, caused increased discomfort, or continued to negatively affect the patient for some time after the event tended to rate their care poorly.

“Although rates of disclosure remain disappointingly low, our findings should encourage more disclosure and allay fears of malpractice lawsuits,” say the authors. “Patients want to be told the truth, and they perceive disclosure as integral to high-quality medical care.”

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López L, Weissman JS, Schneider EC, Weingart SN, Cohen AP, & Epstein AM (2009) Disclosure of Hospital Adverse Events and Its Association With Patients’ Ratings of the Quality of Care. Arch Intern Med 169 (20): 1888-1894. URL: Here

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Got breast cancer? Get to your greengrocers!

Fruit & VegFresh fruit and vegetables can inhibit the growth of breast cancer tumors and reduce the risk of death in women who already have breast cancer, say two new studies.

The first study is one of several on the effects of fresh apple extracts in rats.  Whole apple extracts have strong antiproliferative and antioxidant activities, thought to be a result of the combination of phytochemicals in the fruit.

This study found that giving rats with mammary tumors a dosage of apple extracts equivalent to one apple a day in humans seriously curtailed the likelihood of tumor growth.  In total, only 57% of rats fed low doses of apple extracts experienced rapid tumor growth over the 24-week study compared with 81% of control animals, who received no apple extracts whatsoever.

Strikingly, only 23% of the rats fed high doses of apple extracts showed signs of tumor proliferation. Scaled up, a human would need to consume six apples a day to benefit from this protective effect.

Rui Hai Liu, Cornell associate professor of food science and one of the study’s authors, said, “We not only observed that the treated animals had fewer tumors, but the tumors were smaller, less malignant and grew more slowly compared with the tumors in the untreated rats.”

A second study of 1,901 women with early-stage breast cancer found that a healthy diet of fruit, vegetables, whole grains, and poultry reduced the risk of death from any cause.

The risk of death in women who stuck rigidly to a ‘prudent’ diet was almost 50% lower than that in women who paid less attention to what they ate.  On the other hand, the risk of death in women who ate a Western diet comprising a high intake of red and processed meats and refined grains was much higher than in less unhealthy women.  These observations were generally not modified by physical activity, being overweight, or smoking.

Interestingly, neither dietary pattern was associated with risk of breast cancer recurrence or death from breast cancer.

The authors conclude that “women diagnosed with early-stage breast cancer might improve overall prognosis and survival by adopting more healthful dietary patterns.”

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Make it a DIET coke break, for the sake of your kidneys

Diet coke breakNew research published in PLoS One has shown that drinking two or more fizzy drinks a day can double a woman’s chance of developing signs of kidney disease – but only if she drinks full-sugar sodas.

David A Shoham and colleagues studied data from more than 9,000 individuals in the population-based National Health and Nutrition Examination Survey (1999–2004). They found that women who drank two or more cans of soda per day were nearly twice as likely to develop early signs of kidney disease compared with women who consumed fewer sugary soft drinks. Women who drank diet soda were not at increased risk of kidney disease, nor were men.

The rise in diabetes, obesity and kidney disease in the US has paralleled an increase in the use of high fructose corn syrup in American food. High fructose corn syrup is used in particular as a cheap way to sweeten fizzy drinks; thus, the authors investigated whether consumption of soft drinks is associated with albuminuria, a sensitive marker of early kidney damage.

In total, 11% of the sample population were found to have albumnuria, and 17% of the study group drank two or more sugary soft drinks per day. Individuals who drank more than two fizzy drinks a day were 40% more likely to have albuminuria than were participants with a more moderate intake of soda. Consumption of diet soda, however, was not associated with albuminura.

When the authors broke down their results by gender, they found that women who reported drinking two or more sodas in the previous 24 hours were 1.86 times more likely to have albuminuria than were women who drank less soda. Drinking fizzy drinks had no significant effect on the risk of albuminuria in men.

An analysis of type of soda showed that consumption of sugary non-colas was most strongly linked with albuminuria, whereas sugary cola and diet cola and non-cola drinks showed no such association.

The authors conclude that the correlation between drinking sugary sodas and albuminuria indicates that high fructose corn syrup is in part responsible for the increase in kidney disease in the US. According to the National Kidney Foundation, about 26 million American adults have chronic kidney disease.

Dr Shoham, however, has said. “I don’t think there is anything demonic about high fructose corn syrup per se … People are consuming too much sugar. The problem with high fructose corn syrup is that it contributes to over consumption. It’s cheap, it has a long shelf life and it allows you to buy a case of soda for less than $10.”
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Shoham DA et al. (2008) Sugary Soda Consumption and Albuminuria: Results from the National Health and Nutrition Examination Survey, 1999–2004 PLoS ONE 3 (10) DOI: 10.1371/journal.pone.0003431

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Government to tackle obesity with Change4Life campaign

Change 4 LifeI recently blogged about the alarming rates of obesity among children in England, with one in four 4-5 year old children and one in three 10-11 year olds in this country obese or overweight. The Foresight report, published in 2007, ominously predicts that by 2050 90% of British children will be overweight or obese.

The British Government has now responded to this issue by launching a huge campaign to persuade the population to switch to a healthier lifestyle. The Change4Life strategy will promote the message “eat well, move more, live longer” on TV, in the press, on billboards and online initially for 3 months, and will continue over 3 years.  The initiative will be supported by £200m of advertising and marketing donated by food companies such as Tesco, Mars, Nestlé and Flora.

Dawn Primarolo, minister for public health, said today: “We are trying to create a lifestyle revolution on a grand scale. There are very serious health consequences with allowing dangerous quantities of fat to build up in our bodies. This is not just an ad campaign – we are calling it a lifestyle revolution – it is a long-running concerted effort to change behavior.”

The television campaign launches on Saturday 3rd January with adverts designed by Aardman Animations, the people behind the much loved plasticine duo Wallace and Gromit.  The engaging clip is designed to warn viewers of the health risks associated with being overweight and is targeted at helping young families change their lifestyle for good.

Change4Life is the biggest Government campaign ever launched and is expected to follow in the success of similar cross-media anti-smoking initiatives.  Unlike anti-smoking public awareness strategies though, this campaign steers away from shock tactics and instead offers practical advice.

Critics have been quick to point out that the involvement of food companies in the campaign is a way for such corporations to cast their brand in a healthy light without actually changing the salt or fat content of their food.  Tam Fry of the National Obesity Forum warned that junk food companies were donating millions to the campaign as a way of heading off the “regulation they fear”.

The Telegraph notes that “neither the leaflets nor the screen advertisements use the word obesity”, preferring instead to state that children could grow up to have “dangerous levels of fat in their body”.  The campaign is designed to avoid pointing the finger at any one group, however, specifically avoiding talking about ‘fat bodies’ and blaming modern life rather than parents.

Let’s hope that the more kindly, blame-free approach of Change4Life gets the people of the UK off the sofa and helps to avert our obesity timebomb.

  • If you’re skeptical, the Big Question in The Independent casts a critical eye over the Change4Life campaign, asking whether the Government can really make us eat less.
  • On the other hand, it you want to get serious about improving your lifestyle there is stacks of information on how to eat better, move more and live longer on the Change4Life website.
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